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| Product Name | Flagellin, TLR5 Mutant, Recombinant, aa1-495, His-Tag |
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| Description | Purity ~95% (SDS-PAGE). Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4. Source: Recombinant protein corresponding to native flagellin [FliC] from Salmonella enterica Serovar Typhimurium strain ATCC14028, aa1-495, contains a substitution of aa90-97 required for TLR5 signaling by a motif from a non-signaling flagellin, fused to His-tag at N-terminal, expressed in E. coli Biological Activity: Does not activate TLR5 in human epithelial cell assays based on NF-kB luciferase fusions, in vivo on expression of CCL20 or IL-6. It can be used as negative control for TLR5 signaling assays. Endotoxin: <0.01EU/ug purified protein (LAL test; Lonza) |
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| Size | 10ug, 3x10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Flagellin, TLR5 Mutant, Recombinant, aa1-495, His-Tag (Phase 1-I Flagellin, fliC, flaF, hag, STM1959) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207184 |
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| Order / More Info | Flagellin, TLR5 Mutant, Recombinant, aa1-495, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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