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| Product Name | Fructose-2,6-bisphosphatase TIGAR, active (TIGAR), Recombinant, Human |
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| Description | Purity ≥96% as determined by SDS-PAGE and HPLC. Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocy |
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| Size | 5ug, 25ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EC 3.1.3.46, TP53-induced glycolysis regulatory phosphatase |
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| Gene, Accession, CAS # | TIGAR_HUMAN, SwissProt: Q9NQ88 |
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| Catalog # | 348055 |
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| Order / More Info | Fructose-2,6-bisphosphatase TIGAR, active (TIGAR), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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