| 产品详情 |
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| Product Name | Pirinixic Acid Aminothiazole |
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| Description | Purity >98%. Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50 s = 0.4 and 0.2 µM, respectively). It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms. Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[4-chloro-6-[[4-(2-naphthalenyl)-2-thiazolyl]amino]-2-pyrimidinyl]thio]-octanoic acid |
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| Gene, Accession, CAS # | CAS: 1492060-44-2 |
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| Catalog # | LS-H9436 |
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| Price | |
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| Order / More Info | Pirinixic Acid Aminothiazole from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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