| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Mediator of DNA damage checkpoint protein 1 |
|---|
| Description | 1892-2082aa; Partial. MW: 36.91kd. Purity >90% as determined by SDS-PAGE. Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation |
|---|
| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.05 mg (Yeast), 0.1 mg (E-Coli) |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | [Nuclear factor with BRCT domains 1] |
|---|
| Gene, Accession, CAS # | MDC1, Gene ID: 9656, Accession: NP_055456.2 |
|---|
| Catalog # | MBS1312936 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Mediator of DNA damage checkpoint protein 1 from MYBIOSOURCE INC. |
|---|
| Product Specific References | 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.Mochan T.A., Venere M., DiTullio R.A. Jr., Halazonetis T.D. Cancer Res. 63:8586-8591(2003) |
|---|
| 产品资料 |
|
|