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| Product Name | Transforming Growth Factor beta1, Recombinant, Human, Ala279-Ser390 |
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| Description | Purity ≥98% by SDS-PAGE of 6ug reduced (+) and non-reduced (-) recombinant human TGFb1. <1% migrates as monomer human TGFb1 under non-reduced (-) conditions. Endotoxin: ≤0.01ng/ug. Transforming Growth Factor beta1 (TGFb1) activities include proliferation, angiogenesis and promotion or inhibition of many immune events. TGFb1 is produced by a number of cell types including regulatory T cells, fibroblasts, epithelial cells, and endothelial cells (3). TGFb1 binds to TBRII homodimer, which then complexes with TBRI homodimer. The oligomeric receptor complex phosphorylates subsets of the SMAD proteins that then act to induce and repress a number of target genes. TGFb1 binding can also activate the Erk2, p38, and JNK pathways via TAK1. TGFb1 appears to promote late stage progression and metastasis in some cancers. Recombinant human TGFb1 contains no tags and the nonglycosylated protein has a calculated MW of 12,794. DTT-reduced protein migrates as a 13kD polypeptide and the non-reduced cysti |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | Transforming Growth Factor beta1, Recombinant, Human, Ala279-Ser390 (TGF beta 1, TGFb1, Camurati Engelmann Disease, CED, Diaphyseal Dysplasia 1 Progressive, DPD1, TGFb1, Differentiation Inhibiting Factor, Cartilage-inducing Factor) |
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| Gene, Accession, CAS # | Gene ID: 7040, SwissProt: P01137 |
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| Catalog # | T8250-13B |
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| Order / More Info | Transforming Growth Factor beta1, Recombinant, Human, Ala279-Ser390 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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