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| Product Name | NANOG, Recombinant, Human, aa1-305, His-Tag (Homeobox Protein NANOG) |
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| Description | Purity ~90% (SDS-PAGE). Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. Source: Recombinant protein corresponding to aa1-305 from human NANOG, fused to His-Tag at N-term |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Homeobox transcription factor Nanog, hNanog |
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| Gene, Accession, CAS # | SwissProt: Q9H9S0 |
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| Catalog # | 374369 |
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| Order / More Info | NANOG, Recombinant, Human, aa1-305, His-Tag (Homeobox Protein NANOG) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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