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| Product Name | DOT1L, Recombinant, Human, aa2-416, GST-tag |
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| Description | Purity ~95% (SDS-PAGE). Dot1L is a non-SET domain containing methyltransferase. It is the only enzyme known to methylate histone 3 at lysine 79, where it catalyzes mono-, di-, and trimethylation. Proper Dot1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation. Dot1L plays an essential role in MLL-rearranged leukemias and is being investigated as a drug-target for these leukemias. Experiments using siRNA or shRNA have shown that knockdown of Dot1L leads to loss of proliferation in lung cancer cells or faster reprogramming and increased yield of induced pluripotent stem cells, respectively. This protein product contains the methyltransferase domain of Dot1L. Source: Recombinant protein corresponding to aa2-416 from the methyltransferase domain of human DOT1L, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~74.1kD (aa2-416 + NT GST Tag) |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DOT1L, Recombinant, Human, aa2-416, GST-tag (Histone Methyltransferase DOT1L, Dot1-like, Disruptor of Telomeric Signaling 1-Like) |
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| Gene, Accession, CAS # | DOT1L, Gene ID: 84444, SwissProt: Q8TEK3 |
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| Catalog # | 219700 |
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| Order / More Info | DOT1L, Recombinant, Human, aa2-416, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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