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| Product Name | ROS1 (G2032R), Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines. The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling. Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain. Source: Recombinant protein corresponding to human ROS1 (G2032R), fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~82kD Specific Activity: 42nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ROS1 (G2032R), Recombinant, Human, GST-Tag (Proto-oncogene Tyrosine-protein Kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, c-ros-1, MCF3, ROS) |
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| Gene, Accession, CAS # | Accession: NM_002944 |
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| Catalog # | 500432 |
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| Order / More Info | ROS1 (G2032R), Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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