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| Product Name | MB21D1, Recombinant, Human, aa161-522, His-SUMO-Tag (Cyclic GMP-AMP Synthase) |
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| Description | Purity ~90% (SDS-PAGE). Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). Source: Recombinant protein corresponding to aa161-522 from human MB21D1, fused to His-SUMO-Tag at N-terminal expressed in E. col |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | cGAMP synthase, cGAS, h-cGAS, 2'3'-cGAMP synthase Mab-21 domain-containing protein 1 |
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| Gene, Accession, CAS # | SwissProt: Q8N884 |
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| Catalog # | 374158 |
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| Order / More Info | MB21D1, Recombinant, Human, aa161-522, His-SUMO-Tag (Cyclic GMP-AMP Synthase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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