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| Product Name | MBNL1, Recombinant, Human, aa1-382, His-SUMO-Tag (Muscleblind-like Protein 1) |
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| Description | Purity ~90% (SDS-PAGE). Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the st-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Source: Recombinant protein corresponding to aa1-382 from human MBNL1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~57kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Triplet-expansion RNA-binding protein |
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| Gene, Accession, CAS # | SwissProt: Q9NR56 |
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| Catalog # | 374162 |
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| Order / More Info | MBNL1, Recombinant, Human, aa1-382, His-SUMO-Tag (Muscleblind-like Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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