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| Product Name | Matrix Metalloproteinase 2, CT, Hemopexin-like Domain, Recombinant, Human, aa445-635 (PEX) |
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| Description | Highly Purified (~95%). Recombinant Human PEX is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo. Moreover, PEX can block angiogenesis and tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX is expressed as inclusion bodies in E. coli and subsequently refolded in vitro to get biological activity. Source: Recombinant protein corresponding to aa445-635 from human PEX, expressed in E. coli. Molecular Weight: ~28.45kD Biological Activity: Measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. AA Sequence: MGLEHSQDPG ALMAP |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209082 |
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| Order / More Info | Matrix Metalloproteinase 2, CT, Hemopexin-like Domain, Recombinant, Human, aa445-635 (PEX) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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