| 产品详情 |
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| Product Name | PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog) |
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| Description | Purity ~97% (HPLC). A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Formula: C16H18IN5 Molecular Weight: 407.3 Solubility: DMSO (0.5mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217685 |
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| Order / More Info | PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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