| 产品详情 |
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| Product Name | PP1 Analog V, 2,3-DMB-PP1 |
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| Description | Purity ~97% (HPLC). A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Formula: C18H23N5 Molecular Weight: 309.4 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217686 |
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| Order / More Info | PP1 Analog V, 2,3-DMB-PP1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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