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| Product Name | PPAR Agonist IX, GQ-16 |
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| Description | Purity ~99% (HPLC). A cell-permeable thiazolidinedione that acts as a PPARg-selective agonist (Ki=160nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARg b-sheet structure, exhibiting no detectable activity towards PPARa, PPARd, or RXRa. Although a weaker PPAPg agonist than Thiazolidinediones (TZDs) family rosiglitazone (Max. fold of transactivation induction =8.57 and 24.8 with 10uM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs. Formula: C19H16BrNO3S Molecular Weight: 418.3 Solubility: DMSO (5mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PPAR Agonist IX, GQ-16 ((Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217688 |
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| Order / More Info | PPAR Agonist IX, GQ-16 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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