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| Product Name | SIRP-alpha, Recombinant, Human |
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| Description | Purity ~90%. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Source: Recombinant protein corresponding to aa27-370 from human SIRP-alpha, fused to C-terminal FLAG and Avi tags, expressed in a HEK293 cell expression system. Molecular Weight: ~40.3kD AA Sequence: GVAGEEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQ |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SIRP-alpha, Recombinant, Human (Tyrosine-protein Phosphatase Non-receptor Type Substrate 1, CD172a, Bit, MyD-1) (Biotin) |
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| Gene, Accession, CAS # | Accession: NP_542970 |
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| Catalog # | 172356 |
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| Price | |
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| Order / More Info | SIRP-alpha, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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