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SIRP alpha, Recombinant, Human (SIRPa, Signal Regulatory Protein, SHPS-1, BIT, p84, CD172a) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | SIRP alpha, Recombinant, Human (SIRPa, Signal Regulatory Protein, SHPS-1, BIT, p84, CD172a) |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤1EU/1ug. Signal regulatory protein alpha (SIRPA, designated CD172a), also called SHPS-1 (SHP substrate 1) and previously, MyD-1 (Myeloid/Dendritic-1), is a monomeric ~90kD type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily.1-4 SIRPs are paired receptors, with similar extracellular domains but differing C-termini and functions.1, 2 The 503 amino acid (aa) human SIRPA contains a 342 aa extracellular domain (ECD), with one V-type, and two C1-type Ig domains, and three potential N-glycosylation sites. It has a 110 aa cytoplasmic sequence with ITIM motifs that recruit tyrosine phosphatases SHP-1 and SHP-2 when phosphorylated.4 Human SIRPA has more than 40 described polymorphisms, including the prominent BIT (Brain Ig-like molecule with Tyrosine-based activation motifs, also called SIRPA2 or PTPNS).5 One reported isoform l |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_542970 |
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| Catalog # | S1013-86Z |
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| Order / More Info | SIRP alpha, Recombinant, Human (SIRPa, Signal Regulatory Protein, SHPS-1, BIT, p84, CD172a) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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