| 产品详情 |
| Edit |   |
|---|
| Product Name | GARP, Recombinant Mouse |
|---|
| Description | Purity ~95% (SDS-PAGE). Leucinerich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant), is an 80kD type I transmembrane glycoprotein (1). Mature mouse LRRC32 consists of a 608 amino acid (aa) extracellular domain (ECD) that contains 22 leucinerich repeats, a 21 aa transmembrane segment, and a 14 aa cytoplasmic domain (2 4). Within the ECD, mouse LRRC32 shares 80 and 94% aa sequence identity with human and rat LRRC32, respectively. LRRC32 is widely expressed during embryogenesis and on adult platelets (4, 5). Among T cells, it is selectively expressed on activated FOXP3+ regulatory T cells (Treg) (6 10). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells (6 8). LRRC32 binds directly to the TGFb latency associated peptide (LAP) and tethers latent TGFb on the surface of activated Treg cells (9, 10). The prese |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | GARP, Recombinant Mouse (Glycoprotein A Repetitions Predominant, GARP Protein, Garpin, D11S833E, Leucine-rich Repeat-containing Protein 32, LRRC32) |
|---|
| Gene, Accession, CAS # | Accession: NP_032028.1 |
|---|
| Catalog # | G2013-71 |
|---|
| Price | |
|---|
| Order / More Info | GARP, Recombinant Mouse from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|