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| Product Name | SIRT1, Recombinant, Human, GST-Tag |
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| Description | Purity ≥ 50% by SDS-PAGE. Human Sirtuin 1 (GenBank Accession No. NM_012238), amino acids 193-741 with N-terminal GST tag, expressed in E. coli expression system. The gene hSIR2 (SIRT1), the human homolog of the S. cerevisiae Sir2 protein known to be involved in cell aging and in the response to DNA damage. Despite its conservation in organisms from bacteria to human and its general requirement for transcriptional silencing in yeast, the function of the Sir 2 protein is unknown. Sir 2, a conserved protein required for silencing in yeast, has recently been found to couple histone deacetylation to cleavage of a high-energy bond in nicotinamide adenine dinucleotide (NAD) and the synthesis of a novel product, O-acetyl- ADP-ribose. In vitro studies have shown Sir 2 to be able to transfer labeled phosphate from NAD to itself and histones. The unusual coupling of deacetylation to cleavage and synthesis of other bonds raises the possibility that deacetylation is not the only crucial function of |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SIRT1, Recombinant, Human, GST-Tag (SIRT1 Sir2-like Proteins (Sirtuins) Type 1, Sirtuin, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S. cerevisiae), Sirtuin Type 1, BA57G10.4, hSIRT1, NAD-dependent Deacetylase SIRT1, NAD-dependent Deacetylase Sirtuin-1, SIR2-like Protein 1, hSIR2, SIR2alpha, Sir2a, SIR2alpha, Sir2a Protein, SIR2L1) |
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| Gene, Accession, CAS # | Accession: NP_036370.2 (Human) |
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| Catalog # | S1013-88A5 |
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| Order / More Info | SIRT1, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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