| 产品详情 |
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| Product Name | Sirtuin-3 Inhibitor, SRT1720 |
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| Description | Purity ~97% (HPLC). A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56uM; Km = 2.44uM), but NAD+-uncompetitive (Ki = 0.34uM; Km = 280uM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10uM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9uM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Formula: C25H23N7OS Molecular Weight: 469.6 Solubility: DMSO (2.5mg/ml, clear, yellow solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Sirtuin-3 Inhibitor, SRT1720 (SIRT3 Inhibitor II, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217793 |
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| Order / More Info | Sirtuin-3 Inhibitor, SRT1720 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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