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| Product Name | Sirtuin 6, Recombinant, Human, aa1-355, His-tag |
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| Description | Purity ~90% (SDS-PAGE). Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. Source: Recombinant protein corresponding to aa1-355 of human Sirtuin 6, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~45kD Endotoxin: <0.1EU/ug (LAL method) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Sirtuin 6, Recombinant, Human, aa1-355, His-Tag (SIRT6, NAD-Dependent Deacetylase Sirtuin-6n Mono-ADP-ribosyltransferase Sirtuin 6n SIR2-like Protein 6n SIR2L6) |
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| Gene, Accession, CAS # | SIRT6, Gene ID: 51548, SwissProt: Q8N6T7 |
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| Catalog # | 301287 |
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| Order / More Info | Sirtuin 6, Recombinant, Human, aa1-355, His-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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