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| Product Name | CDC42 Inhibitor III, ZCL278 |
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| Description | Purity ~94% (HPLC). A cell-permeable, non-cytotoxic, aqueous soluble (181uM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1h pretreatment; 50uM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50uM). Solubility: DMSO Primary Target: CDC42 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDC42 Inhibitor III, ZCL278 (4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)acetamide, CDC42 GTPase Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217262 |
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| Order / More Info | CDC42 Inhibitor III, ZCL278 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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