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| Product Name | Vimentin, Recombinant, Human (FLJ36605, VIM) |
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| Description | Purity ~ 95%; Determined by SDS-gel electrophoresis. Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastic spread. Primary colorectal carcinomas display aberrant expression of Vimentin, and have activated Notch and TGF-beta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated Vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of Vimentin expression inhibits migraion and invasion of colon and breast cancer cell lines. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms. Recombinant Human Vim |
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| Size | 20ug, 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | V2122-15 |
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| Order / More Info | Vimentin, Recombinant, Human (FLJ36605, VIM) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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