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| Product Name | GANT 61 |
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| Description | Purity >98%. Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 61 is a GLI antagonist, inhibiting GLI1 activation of gene expression with an IC50 value of 5 µM. It does not affect signaling through NF-?B, glucocorticoid receptor, MAPK, HGF, C/EBPAlpha, or HIF-1, supporting specificity for the Hedgehog pathway. GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated GLI1 levels, and prevent the development of 22Rv1 tumors in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis (methylene)]bis (N,N-dimethyl-benzenamine), NSC 136476 |
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| Gene, Accession, CAS # | CAS: 500579-04-4 |
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| Catalog # | LS-H7902 |
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| Price | |
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| Order / More Info | GANT 61 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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