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| Product Name | Heparanase, Recombinant, Human, aa36-543, His-Tag |
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| Description | Purity ~95% (SDS-PAGE). Heparanase (HPSE) selectively cleaves heparan sulfate at specific sites on heparan sulfate proteoglycans (HSPGs) (1, 2, 3, 4). The enzyme is synthesized as an inactive 65kD proenzyme that is secreted via the Golgi apparatus and associates with the cell membrane through interaction with HSPGs (5). It is then endocytosed and transferred to lysosomes (6) where cathepsin L activates it by removing an internal inhibitory peptide, forming a heterodimer composed of an 8kD and a 50kD subunit (7, 8). Under certain stimuli, the active enzyme is transferred back to the cell surface, where it participates in extracellular matrix degradation and remodeling (9). HPSE facilitates cell migration associated with metastasis, wound healing and inflammation (10). An increase in its activity is associated with an increase in VEGF activity, which further enhances angiogenesis (11). HPSE also enhances shedding of syndecans and increases endothelial invasion and angiogenesis in myeloma |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Heparanase, Recombinant, Human, aa36-543, His-Tag (Active Heparanase, HPSE, Endo-glucoronidase, HPA1, HPR1, HPSE, HSE1) |
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| Gene, Accession, CAS # | Accession: AF144325 |
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| Catalog # | 145801 |
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| Order / More Info | Heparanase, Recombinant, Human, aa36-543, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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