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| Product Name | AP2M1, Recombinant, Human, aa1-435, His-Tag (AP-2 Complex Subunit mu) |
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| Description | Purity ~90% (SDS-PAGE). Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AP-2 mu chain, Adaptin-mu2 Adaptor protein complex, AP-2 subunit mu Adaptor-related protein complex 2 subunit, muClathrin assembly protein complex 2 mu medium chain, Clathrin coat assembly protein AP50 Clathrin coat-associated protein AP50HA2 50kD subunit Plasma membrane adaptor AP-2 50kD protein |
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| Gene, Accession, CAS # | SwissProt: Q96CW1 |
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| Catalog # | 372282 |
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| Order / More Info | AP2M1, Recombinant, Human, aa1-435, His-Tag (AP-2 Complex Subunit mu) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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