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| Product Name | TRAIL, Recombinant, Human, aa114-281 |
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| Description | Purity ~95% (SDS-PAGE). TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL- R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRUNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRUNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Source: Recombinant protein corresponding to aa114-281 from human TRAIL, expressed in E. coli. Molecular Weight: ~19.6kD (169aa) Endotoxin: <1EU/1ug (determined by LAL method) Biological Activity: Measured in a cell cytotoxicity assay using Jurkat human T lymphocyte. The ED50 for this effect is ≤1ng/ml. AA |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TRAIL, Recombinant, Human, aa114-281 (TNF-Related Apoptosis Inducing Ligand, TNFSF10, Apo-2L, APO2L, CD253, TL2) |
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| Gene, Accession, CAS # | Accession: NP_003801 |
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| Catalog # | 377993 |
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| Order / More Info | TRAIL, Recombinant, Human, aa114-281 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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