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| Product Name | TRAIL, Recombinant, Mouse (TNF-Related Apoptosis Inducing Ligand, Apo2 Ligand) |
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| Description | Purity ≥95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤0.01EU/ug (LAL). TNF-related apoptosis-inducing ligand (TRAIL), also called apoptosis 2 ligand (Apo2L) for its similarity in sequence, structure, and function to Fas Ligand/Apo1L, is a 33-35 kD type II transmembrane glycoprotein of the tumor necrosis factor superfamily, designated TNFSF10. Mouse TRAIL cDNA encodes a 17 amino acid (aa) N-terminal intracellular domain, a 20 aa transmembrane domain and a 253 aa extracellular domain. Like most TNF family members, TRAIL is bioactive as a homotrimer. Unlike other TNF family members, a zinc ion complexed by human Cys 230 (mouse Cys 240) of each of the three monomers is critical for structural stability. Either transmembrane or cysteine protease-released soluble sTRAIL induce apoptosis of many transformed cell lines, but rarely of normal cells. Accordingly, TRAIL is suggested to have a role in tumor surveillance. Mice with genetically disrupted TRAIL have defect |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_003801 |
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| Catalog # | T8180-04M |
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| Order / More Info | TRAIL, Recombinant, Mouse (TNF-Related Apoptosis Inducing Ligand, Apo2 Ligand) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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