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| Product Name | TRAIL, Recombinant, Mouse (TNF-related Apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2) |
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| Description | Purity ~95% (SDS-PAGE). TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic ``death domain'', which activates the cell's apoptotic machinery. Recombinant mouse TRAIL is a 174aa polypeptide, consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein. Source: Recombinant protein corresponding to 174aa from mouse TRAIL, expressed in E. coli. Molecular Weight: ~20kD Biological Activity: Assay #1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100ng/ml. ?Assay #2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40-60ng/ml. Endotoxin: <0.1ng/ug of protein (<1E |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2 |
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| Gene, Accession, CAS # | TRAIL, Gene ID: 22035, SwissProt: P50592 |
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| Catalog # | 220348 |
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| Order / More Info | TRAIL, Recombinant, Mouse (TNF-related Apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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