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| Product Name | TRAIL, Recombinant, Mouse (TNF-related apoptosis-inducing Ligand, TNFSF10, TL2) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells.TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5.These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domainrdquo, which activates the cell's apoptotic machinery.Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0kD), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein. Biological Activity: Assay#1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100ng/ml. Assay#2:Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0ng/ml. AA Sequence: MRGGRPQKVAAHITGITRRSNSALIPISKDGKTLGQKIESWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSKDKVRT |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143529 |
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| Order / More Info | TRAIL, Recombinant, Mouse (TNF-related apoptosis-inducing Ligand, TNFSF10, TL2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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