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| Product Name | TRAIL-R2,Fc, Recombinant, Human |
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| Description | Purity >95% (SDS-PAGE). TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Biological Activity: Blocks human or mouse TRAIL activity in a concentration of 1-10ug/ml. Sequence: The extracellular domain of human TRAIL-R2 (aa 52-212) is fused to the Fc portion of human IgG1. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TRAIL-R2,Fc, Recombinant, Human (DR5, TNFRSF 10B, CD262, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRAIL Receptor 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 45361 |
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| Order / More Info | TRAIL-R2,Fc, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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