| 产品名称 |
TRAIL, R1 specific, soluble, Recombinant, Human (TRAIL, Apo-2L, TNFSF10, CD253) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | TRAIL, R1 specific, soluble, Recombinant, Human (TRAIL, Apo-2L, TNFSF10, CD253) |
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| Description | Purity >98% (SDS-PAGE). TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Biological Activity: Induces apoptosis in a concentration range of 20-500ng/ml of TRAIL-R1 (DR4) expressing cell lines (e.g. RAMOS). It is inefficient to kill via TRAIL-R2 (DR5) in Jurkat cells. The activity depends on the relative cellular surface expression of TRAIL-R1 compared to other death-signaling TRAIL-Rs. Concentrations of KillerTRAIL™-R1 to induce apoptosis may vary depending on the cell type. Note: This protein does not require a cross-linking enhancer for its potent biological activity. Sequence: The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-t |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TRAIL, Apo-2L, TNFSF10, CD253 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 45365 |
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| Order / More Info | TRAIL, R1 specific, soluble, Recombinant, Human (TRAIL, Apo-2L, TNFSF10, CD253) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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