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| Product Name | GRK5, Active, Recombinant, Human, GST-tag (G-Protein-Coupled Receptor Kinase 5) |
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| Description | Purity ~95% (SDS-PAGE). G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Haribabu and Snyderman (1) identified GRK5 and GRK6. GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Bullrich (2) used a rodent-human hybrid panel to map 2 newly identified members of the GRK family: GPRK5 and GPRK6 to 10q24-qter and 5q35, respectively. Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRKs (3). MIP2 induce |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | grk-5, grk 5, Active GRK5, GRK5, human GRK5, active kinase, active kinases, GRK, recombinant GRK5, recombinant GRK, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | GRK5, Gene ID: 2869, SwissProt: P34947 |
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| Catalog # | 219814 |
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| Order / More Info | GRK5, Active, Recombinant, Human, GST-tag (G-Protein-Coupled Receptor Kinase 5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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