| 产品详情 |
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| Product Name | Ko 143 |
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| Description | Purity >98%. Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50 s = 23 and 26 nM, respectively). It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester |
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| Gene, Accession, CAS # | CAS: 461054-93-3 |
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| Catalog # | LS-H8357 |
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| Price | |
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| Order / More Info | Ko 143 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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