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| Product Name | MAPKAP Kinase 2, Inactive, Recombinant, Human, GST-Tag |
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| Description | Purity ≥45%. MAPKAP kinase-2 (or MK2) is an acronym for mitogen-activated protein kinase-activated protein kinase-2. This enzyme is phosphorylated and activated by Erks and p38 MAPK in vitro. While multiple residues of MK2 are phosphorylated in vivo in response to stress, only four of the residues Thr25, Thr222, Ser272 and Thr334 are phosphorylated by p38 in an in vitro kinase assay. MK2 is serine-threonine protein kinase that contains a proline rich sequence and two putative SH3-binding sites. MK2 phosphorylates downstream components on a consensus Pro-X-Ser/Thr-Pro motif. The bestcharacterized MK2 substrate is hsp27. Although unknown, the physiological function of MK2 may be to increase stress resistance. MK2 is an essential component in the inflammatory response that regulates biosynthesis of TNF-a at a posttranscriptional level and MK2 is rapidly phosphorylated and activated in response to cytokines, stress and chemotactic factors. Source: Recombinant human MAPKAPK2, full length, w |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MAPKAP Kinase 2, Inactive, Recombinant, Human, GST-Tag (Mitogen-activated Protein Kinase-activated Protein Kinase 2, MAP Kinase-activated Protein Kinase 2, MAPK-activated Protein Kinase 2, MAPKAPK2, MAPKAPK-2, MK2) |
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| Gene, Accession, CAS # | Accession: NM_032960 |
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| Catalog # | M2355-01Q |
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| Order / More Info | MAPKAP Kinase 2, Inactive, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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