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| Product Name | MAPKAPK3, Recombinant, Human, aa1-382, His-Tag |
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| Description | Purity ~95% (SDS-PAGE). MAP kinase-activated protein kinase 3, also known as MAPKAPK3, is involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Source: Recombinant protein corresponding to aa1-382 from human MAPKAPK3 at N-terminal, fused to His-tag expressed in E.coli. Molecular Weight: ~45.4kD (405aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDGETAE EQGGPVPPPV APGGPGLGGA PGGRREPKKY AVTDDYQLSK QVLGLGVNGK VLECFHRRTG QKCALKLLYD SPKARQEVDH HWQASGGPHI VCILDVYENM HHGKRCLLII MECMEGGELF SRIQERGDQA FTEREAAEIM RDIGTAIQFL HSHNIAHRDV KPENLLYTSK EKDAVLKLTD FG |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MAPKAPK3, Recombinant, Human, aa1-382, His-Tag (MAP Kinase-activated Protein Kinase 3, 3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 138692 |
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| Order / More Info | MAPKAPK3, Recombinant, Human, aa1-382, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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