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| Product Name | Akt Pathway, phosphorylated BioAssay™ Sample Kit |
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| Description | Purified by protein A and peptide affinity chromatography. Synthetic phosphopeptides corresponding to residues surrounding Ser473 or Thr308 of mouse Akt, Ser9 of human GSK-3beta, Ser256 of human FKHR, Ser380 of human PTEN or Ser241 of human PDK1. Each antibody recognizes the phosphorylated form of its specific target. Akt, also referred to as PKB or Rac, plays a critical role in controlling the balance between survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors, and functions in a wortmannin-sensitive pathway involving PI3 kinase (2,3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and also by phosphorylation within the C-terminus at Ser473. Akt functions to promote cell survival by inhibiting apoptosis by means of its ability to phosphorylate and inactivate several targets, including Bad (5), Forkhead transcription factors (6) and caspase-9. PTEN phosphatase is a major ne |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A1124-10A |
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| Order / More Info | Akt Pathway, phosphorylated BioAssay™ Sample Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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