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| Product Name | PEDF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE, HPLC). PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50kD glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related di |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PEDF, Recombinant, Human (Pigment Epithelium-Derived Factor, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35) |
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| Gene, Accession, CAS # | PEDF, Gene ID: 5176, SwissProt: P36955 |
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| Catalog # | 220147 |
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| Order / More Info | PEDF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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