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| Product Name | PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1) |
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| Description | Purity ≥ 90% by SDS-PAGE, HPLC. Recombinant Human PEDF (Pigment epithelium-derived factor, SerpinF1, EPC-1) is a noninhibitory serpin with neurotrophic, anti- angiogenic, and anti-tumorigenic properties. It is a 50kD glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti- angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activiti |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P3140-02A |
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| Order / More Info | PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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