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| Product Name | MEOX1, Recombinant, Human, aa1-254, GST-Tag (Homeobox Protein MOX-1) |
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| Description | Purity ~90% (SDS-PAGE). Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Source: Recombinant protein corresponding to aa1-254 from human MEOX1, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~55.0kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mesenchyme homeobox 1 |
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| Gene, Accession, CAS # | SwissProt: P50221 |
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| Catalog # | 374189 |
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| Order / More Info | MEOX1, Recombinant, Human, aa1-254, GST-Tag (Homeobox Protein MOX-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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