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| Product Name | Recombinant Human ACVR2B / ActivinR-IIB Protein (Fc tag) |
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| Description | Purity >97 % as determined by SDS-PAGE. Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conser |
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| Size | 0.1 mg, 0.2 mg |
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| Concentration | n/a |
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| Applications | The recombinant human ACVR2B/Fc chimera is a disulfide-linked homodimer generated after removal of the signal peptide. The reduced monomer comprises 354 amino acids and predicts a molecular mass of 40.0 kDa. As a result of glycosylation, the monomer migrates as an approximately 60-65 kDa protein in SDS-PAGE under reducing conditions. |
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| Other Names | [ACVR2B, ACTRIIB, ActR-IIB, MGC116908] |
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| Gene, Accession, CAS # | ACVR2B, Gene ID: 93, Accession: NP_001097.2 |
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| Catalog # | MBS2546395 |
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| Order / More Info | Recombinant Human ACVR2B / ActivinR-IIB Protein (Fc tag) from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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