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| Product Name | Brain-Derived Neurotrophic Factor, Recombinant, Human (BDNF) |
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| Description | Purity ≥ 98% (SDS-PAGE, HPLC) Endotoxin: ≤ 0.1ng/ug (1EU/ug). BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0kD homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and mouse BDNF sequences are identical. Biological Activity: Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1ug |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B2700 |
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| Order / More Info | Brain-Derived Neurotrophic Factor, Recombinant, Human (BDNF) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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