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| Product Name | HDAC3/NcoR2 Complex, Recombinant, Human, GST-Tag (Histone Deacetylase 3) |
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| Description | Purity ≥ 50% by SDS-PAGE. HDAC3 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC3 probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. It is required to repress transcription of the POU1F1 transcription factor. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription HDAC1 (human, recombinant, full length, C-terminal His tag, MW: 49.7kD) and human NCOR2 (aa 395-489 N-terminal GST tag, MW: 39 kD) (GenBank Accession No. NM_006312) co-expressed in baculovirus e |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_003883,NM_006312) |
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| Catalog # | H1827-55D |
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| Order / More Info | HDAC3/NcoR2 Complex, Recombinant, Human, GST-Tag (Histone Deacetylase 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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