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| Product Name | PARP1, Recombinant, Human, aa2-331, His-Tag (Poly [ADP-ribose] Polymerase 1) |
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| Description | Purity ~90% (SDS-PAGE). Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Source: Recombinant protein corr |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ADP-ribosyltransferase diphtheria toxin-like 1, ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1 |
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| Gene, Accession, CAS # | SwissProt: P09874 |
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| Catalog # | 374619 |
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| Order / More Info | PARP1, Recombinant, Human, aa2-331, His-Tag (Poly [ADP-ribose] Polymerase 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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