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| Product Name | RAF1, GST-Tag, Recombinant (NS5, CRAF, Raf-1, c-Raf, RAF Proto-Oncogene Serine/Threonine-Protein Kinase) |
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| Description | Lysate. This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. Source: Partial length protein corresponding to of RAF1, fused to GST-Tag at N-terminal, expressed in E. coli. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the r |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | RAF1, Gene ID: 5894, Accession: NP_002871, SwissProt: P04049 |
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| Catalog # | 500922 |
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| Order / More Info | RAF1, GST-Tag, Recombinant (NS5, CRAF, Raf-1, c-Raf, RAF Proto-Oncogene Serine/Threonine-Protein Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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