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| Product Name | RAF1, Recombinant, Human, aa1-648, His-SUMO-Tag (RAF Proto-oncogene Serine/threonine-protein Kinase) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the Extracellular domain signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Proto-oncogene c-RAF, cRaf, Raf-1 |
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| Gene, Accession, CAS # | SwissProt: P04049 |
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| Catalog # | 374988 |
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| Order / More Info | RAF1, Recombinant, Human, aa1-648, His-SUMO-Tag (RAF Proto-oncogene Serine/threonine-protein Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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