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| Product Name | MYLIP, Recombinant, Human, aa1-445, GST-Tag (E3 Ubiquitin-protein Ligase MYLIP) |
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| Description | Purity ~90% (SDS-PAGE). E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Source: Recombinant protein corresponding to aa1-445 from human MYLIP, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~76.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Inducible degrader of the LDL-receptor, Idol Myosin regulatory light chain interacting protein, MIR |
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| Gene, Accession, CAS # | SwissProt: Q8WY64 |
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| Catalog # | 374349 |
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| Order / More Info | MYLIP, Recombinant, Human, aa1-445, GST-Tag (E3 Ubiquitin-protein Ligase MYLIP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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