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| Product Name | Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a) |
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| Description | Purity ~95% (RP-HPLC, SDS-PAGE). Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in cellular and systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1 subunit and one of three subunits (Hif-1, Hif-2 or Hif-3). The activation of Hif-1 (is closely associated with a variety of tumors and oncogenic pathways. Hif-1 (consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatory domains, including two transactivation domains (TAD), an oxygen-dependent degradation (ODD) domain, and inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischem |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209019 |
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| Order / More Info | Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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