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| Product Name | Hypoxia Inducible Factor 1 alpha, Recombinant, Human (HIF-1a) |
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| Description | Purity ≥ 95% by SDS-PAGE. Purified by conventional chromatography techniques. Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha). The activation of HIF-1alpha is closely associated with a variety of tumors and oncogenic pathways. HIF-1alpha consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatiory domains, including two transactivation domains (TAD), an oxygen-dependent degradation (ODD) domain, and inhibitory domains. HIF-1alpha (aa530-826) contains two TAD and inhibitory domain. Amino Acid Sequence: MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SL |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H9804-01B |
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| Order / More Info | Hypoxia Inducible Factor 1 alpha, Recombinant, Human (HIF-1a) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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