| 产品详情 |
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| Product Name | IBMX |
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| Description | IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50 µM for PDE1-5, PDE7, and PDE11. PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists. Suppresses alpha-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 µM). |
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| Size | 1 gm |
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| Concentration | n/a |
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| Applications | Activator or Inhibitor |
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| Other Names | PDE inhibitor |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P019-1GM |
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| Price | |
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| Order / More Info | IBMX from ARBOR ASSAYS, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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