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| Product Name | Platelet Factor 4, Human |
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| Description | Purity ~95% (SDS-PAGE, RP-HPLC). Platelet factor-4 is a 70aa protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8kD protein consisting of 70aa residues. Source: Recombinant corresponding to human PF 4 expressed in human platelets. AA Sequence: The sequence of the first four N-terminal aa was determined and was found to be Glu-Ala-Glu-Glu. Molecular Weight: ~7.8kD Biological Activity: Binding |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Platelet Factor 4, Human (PF4, PF-4, C-X-C Motif Chemokine 4, CXCL4, Iroplact, Oncostatin-A, SCYB4) |
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| Gene, Accession, CAS # | SwissProt: P02776 |
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| Catalog # | P4258-25G |
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| Order / More Info | Platelet Factor 4, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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